PrimePCR™ lncRNA® Probe Assay:PTPN1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression.

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   Same primer pair as used in SYBR assay qhsaLED0104562

List Price:    $247.00
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PrimePCR™ IncRNA PreAmp for Probe Assay: PTPN1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ IncRNA Template for Probe Assay: PTPN1, Human
Reaction:     4 billion copies/200 µl
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   lncRNA Expression
Unique Assay ID:   qhsaLEP0181802
Assay Design:   exonic
Chromosome Location:   chr20:50584375-50584524question
Amplicon Length:   120
Refseq Transcripts Amplified:   NM_002827,NM_001278618
Splice Variants Targeted:   ENST00000541713 ENST00000371621
LNCipedia Splice Variants Targeted:   lnc-PTPN1-3:1

Gene Information

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitotic cycle and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase as well as JAK2 and TYK2 kinases which implicated the role of this PTP in cell growth control and cell response to interferon stimulation. [provided by RefSeq Jul 2008]

Gene Symbol:   PTPN1
Gene Name:   protein tyrosine phosphatase, non-receptor type 1
Aliases:   PTP1B
RefSeq:   NC_000020.10 NG_012119.1 NT_011362.10
Ensembl:   ENSG00000196396
LNCipedia:   lnc-PTPN1-3
Entrez:   5770
Chromosome Mapping:   20q13.1-q13.2
Gene Strand:   Not Available

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