PrimePCR™ SYBR® Green Assay: PSEN1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

Info:   Recommended - best coverage

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qHsaCED0005570
Assay Design:   Exonic
Chromosome Location:   14:73614714-73614803question
Amplicon Length:   60
Splice Variants Targeted:   ENST00000557356 ENST00000556864 ENST00000556533 ENST00000556951 ENST00000557293 ENST00000553719 ENST00000553599 ENST00000556011 ENST00000394157 ENST00000324501 ENST00000357710 ENST00000555254 ENST00000553447 ENST00000554131 ENST00000557037 ENST00000394164 ENST00000556066 ENST00000557511 ENST00000261970 ENST00000344094

Gene Information

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase an enzyme that cleaves APP. Also it is thought that the presenilins are involved in the cleavage of the Notch receptor such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene the full-length nature of only some have been determined. [provided by RefSeq Aug 2008]

Gene Symbol:   PSEN1
Gene Name:   presenilin 1
Aliases:   AD3, FAD, PS-1, PS1, S182
RefSeq:   NC_000014.8 NG_007386.2 NT_026437.12
Ensembl:   ENSG00000080815
Entrez:   5663
Chromosome Mapping:   14q24.3

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