PrimePCR™ Probe Assay: NFKB1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0024363
Assay Design:   Exonic
Chromosome Location:   4:103500060-103500165question
Amplicon Length:   76
Splice Variants Targeted:   ENST00000226574 ENST00000394820 ENST00000505458 ENST00000508584

Gene Information

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines oxidant-free radicals ultraviolet irradiation and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Sep 2009]

Gene Symbol:   NFKB1
Gene Name:   nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Aliases:   DKFZp686C01211, EBP-1, KBF1, MGC54151, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, p105, p50
RefSeq:   NC_000004.11 NT_016354.19
Ensembl:   ENSG00000109320
Entrez:   4790
Chromosome Mapping:   4q24

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