PrimePCR™ Probe Assay: CDH1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049339
Assay Design:   exonic
Chromosome Location:   16:68845593-68845726question
Amplicon Length:   104
Splice Variants Targeted:   ENST00000261769 ENST00000422392

Gene Information

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric breast colorectal thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation invasion and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq Jul 2008]

Gene Symbol:   CDH1
Gene Name:   cadherin 1, type 1, E-cadherin (epithelial)
RefSeq:   NM_004360
Ensembl:   ENSG00000039068
Entrez:   999
Chromosome Mapping:   chr16:68771194-68869444

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