PrimePCR™ Probe Assay: FGFR4, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: FGFR4, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: FGFR4, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0053176
Assay Design:   exonic
Chromosome Location:   5:176516563-176517399question
Amplicon Length:   111
Splice Variants Targeted:   ENST00000353332 ENST00000296003 ENST00000351233 ENST00000225402 ENST00000209728 ENST00000577249 ENST00000292408 ENST00000503708 ENST00000393648 ENST00000514472 ENST00000502906 ENST00000510911 ENST00000513166 ENST00000393637 ENST00000292410

Gene Information

The protein encoded by this gene is a member of the fibroblast growth factor receptor family where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region composed of three immunoglobulin-like domains a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors setting in motion a cascade of downstream signals ultimately influencing mitogenesis and differentiation. The genomic organization of this gene compared to members 1-3 encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and although its specific function is unknown it is overexpressed in gynecological tumor samples suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq Jul 2008]

Gene Symbol:   FGFR4
Gene Name:   fibroblast growth factor receptor 4
Aliases:   CD334, JTK2, MGC20292, TKF
RefSeq:   NC_000005.9 NT_023133.13 NG_012067.1
Ensembl:   ENSG00000160867
Entrez:   2264
Chromosome Mapping:   5q35.1-qter

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