PrimePCR™ Probe Assay: GPX1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0039727
Assay Design:   exonic
Chromosome Location:   3:49394616-49394747question
Amplicon Length:   102
Splice Variants Targeted:   ENST00000419783 ENST00000419349

Gene Information

This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine which occurs at the active site of glutathione peroxidase and is coded by UGA that normally functions as a translation termination codon. In addition this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region which includes three alleles with five six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   GPX1
Gene Name:   glutathione peroxidase 1
Aliases:   GSHPX1, MGC14399, MGC88245
RefSeq:   NC_000003.11 NG_012264.1 NT_022517.18
Ensembl:   ENSG00000233276
Entrez:   2876
Chromosome Mapping:   3p21.3

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