PrimePCR™ Probe Assay: HLA-DRA, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: HLA-DRA, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: HLA-DRA, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0040019
Assay Design:   exonic
Chromosome Location:   6:32412568-32412716question
Amplicon Length:   119
Splice Variants Targeted:   ENST00000416883 ENST00000411505 ENST00000414698 ENST00000418111 ENST00000546379 ENST00000383127 ENST00000434866 ENST00000383259 ENST00000383258 ENST00000551750 ENST00000442960 ENST00000415767 ENST00000549531 ENST00000553193 ENST00000427753 ENST00000411524 ENST00000395388 ENST00000374982

Gene Information

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes dendritic cells macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide exons 2 and 3 encode the two extracellular domains and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1 DRB3 DRB4 and DRB5. [provided by RefSeq Jul 2008]

Gene Symbol:   HLA-DRA
Gene Name:   major histocompatibility complex, class II, DR alpha
Aliases:   FLJ51114, HLA-DRA1, MLRW
RefSeq:   NC_000006.11 NG_002392.2 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1 NT_167249.1
Ensembl:   ENSG00000204287
Entrez:   3122
Chromosome Mapping:   6p21.3

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