PrimePCR™ Probe Assay: CASR, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049329
Assay Design:   exonic
Chromosome Location:   3:122003199-122003294question
Amplicon Length:   66
Splice Variants Targeted:   ENST00000490131 ENST00000498619 ENST00000296154

Gene Information

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia familial isolated hypoparathyroidism and neonatal severe primary hyperparathyroidism. [provided by RefSeq Jul 2008]

Gene Symbol:   CASR
Gene Name:   calcium-sensing receptor
Aliases:   CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, MGC138441, NSHPT, PCAR1
RefSeq:   NC_000003.11 NG_009058.1 NT_005612.16
Ensembl:   ENSG00000036828
Entrez:   846
Chromosome Mapping:   3q13

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