PrimePCR™ Probe Assay: YWHAE, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0050518
Assay Design:   exonic
Chromosome Location:   17:1303388-1303495question
Amplicon Length:   78
Splice Variants Targeted:   ENST00000264335 ENST00000571732 ENST00000573026 ENST00000575977

Gene Information

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases RAF1 and IRS1 proteins suggesting its role in diverse biochemical activities related to signal transduction such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants one protein-coding and the other non-protein-coding have been found for this gene. [provided by RefSeq Aug 2008]

Gene Symbol:   YWHAE
Gene Name:   tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Aliases:   14-3-3E, FLJ45465, FLJ53559, KCIP-1, MDCR, MDS
RefSeq:   NC_000017.10 NG_009233.1 NT_010718.16
Ensembl:   ENSG00000108953
Entrez:   7531
Chromosome Mapping:   17p13.3

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