PrimePCR™ Probe Assay: PTPN6, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0050653
Assay Design:   exonic
Chromosome Location:   12:7060879-7061238question
Amplicon Length:   79
Splice Variants Targeted:   ENST00000543115 ENST00000399448 ENST00000538715 ENST00000318974 ENST00000536521 ENST00000541698 ENST00000542462 ENST00000447931 ENST00000456013 ENST00000601360 ENST00000595832 ENST00000599028 ENST00000601126 ENST00000595623 ENST00000594686 ENST00000594402 ENST00000594603 ENST00000593615

Gene Information

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitotic cycle and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains which act as protein phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene which encode distinct isoforms have been reported. [provided by RefSeq Jul 2008]

Gene Symbol:   PTPN6
Gene Name:   protein tyrosine phosphatase, non-receptor type 6
Aliases:   HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
RefSeq:   NC_000012.11 NT_009759.16
Ensembl:   ENSG00000111679
Entrez:   5777
Chromosome Mapping:   12p13

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