PrimePCR™ Probe Assay: RUNX2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0051329
Assay Design:   exonic
Chromosome Location:   6:45459747-45479990question
Amplicon Length:   83
Splice Variants Targeted:   ENST00000371432 ENST00000352853 ENST00000541979 ENST00000359524 ENST00000576263 ENST00000371436 ENST00000371438 ENST00000465038

Gene Information

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or with more affinity as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq Jul 2008]

Gene Symbol:   RUNX2
Gene Name:   runt-related transcription factor 2
Aliases:   AML3, CBFA1, CCD, CCD1, MGC120022, MGC120023, OSF-2, OSF2, PEA2aA, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1
RefSeq:   NC_000006.11 NT_007592.15 NG_008020.1
Ensembl:   ENSG00000124813
Entrez:   860
Chromosome Mapping:   6p21

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