PrimePCR™ Probe Assay: ACTN1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0057507
Assay Design:   exonic
Chromosome Location:   14:69387725-69387822question
Amplicon Length:   68
Splice Variants Targeted:   ENST00000193403 ENST00000394419 ENST00000438964 ENST00000376839 ENST00000538545 ENST00000555616 ENST00000556433 ENST00000553370 ENST00000553779 ENST00000556571

Gene Information

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions where it is involved in binding actin to the membrane. In contrast skeletal cardiac and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle cytoskeletal alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   ACTN1
Gene Name:   actinin, alpha 1
Aliases:   FLJ40884, FLJ54432
RefSeq:   NC_000014.8 NT_026437.12
Ensembl:   ENSG00000072110
Entrez:   87
Chromosome Mapping:   14q24.1-q24.2,14q24,14q22-q24

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