PrimePCR™ Probe Assay: PDGFRA, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0026381
Assay Design:   Intron-spanning
Chromosome Location:   4:55124944-55127353question
Amplicon Length:   103
Splice Variants Targeted:   ENST00000257290 ENST00000508170 ENST00000512143 ENST00000503856 ENST00000504461 ENST00000512522

Gene Information

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development wound healing and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome somatic and familial gastrointestinal stromal tumors and a variety of other cancers. [provided by RefSeq Mar 2012]

Gene Symbol:   PDGFRA
Gene Name:   platelet-derived growth factor receptor, alpha polypeptide
Aliases:   CD140A, MGC74795, PDGFR2, RHEPDGFRA
RefSeq:   NC_000004.11 NG_009250.1 NT_022853.15
Ensembl:   ENSG00000134853
Entrez:   5156
Chromosome Mapping:   4q12

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