PrimePCR™ Probe Assay: RASGRP1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0030668
Assay Design:   Intron-spanning
Chromosome Location:   15:38798052-38799964question
Amplicon Length:   78
Splice Variants Targeted:   ENST00000310803 ENST00000450598 ENST00000539159 ENST00000415523 ENST00000431814 ENST00000541438 ENST00000414708

Gene Information

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq Jul 2008]

Gene Symbol:   RASGRP1
Gene Name:   RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Aliases:   CALDAG-GEFI, CALDAG-GEFII, MGC129998, MGC129999, RASGRP, V, hRasGRP1
RefSeq:   NC_000015.9 NT_010194.17 NG_023268.1
Ensembl:   ENSG00000172575
Entrez:   10125
Chromosome Mapping:   15q14

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