PrimePCR™ Probe Assay: ROCK1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0031274
Assay Design:   Intron-spanning
Chromosome Location:   18:18531253-18533618question
Amplicon Length:   146
Splice Variants Targeted:   ENST00000399799

Gene Information

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein a downstream effector of Rho phosphorylates and activates LIM kinase which in turn phosphorylates cofilin inhibiting its actin-depolymerizing activity. [provided by RefSeq Jul 2008]

Gene Symbol:   ROCK1
Gene Name:   Rho-associated, coiled-coil containing protein kinase 1
Aliases:   MGC131603, MGC43611, P160ROCK, PRO0435
RefSeq:   NC_000018.9 NT_010966.14
Ensembl:   ENSG00000067900
Entrez:   6093
Chromosome Mapping:   18q11.1

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