PrimePCR™ Probe Assay: CSE1L, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0031938
Assay Design:   Intron-spanning
Chromosome Location:   20:47675005-47679812question
Amplicon Length:   125
Splice Variants Targeted:   ENST00000262982 ENST00000396192 ENST00000542325 ENST00000417408

Gene Information

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS while importin-beta mediates translocation through the nuclear pore complex. After translocation RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq Jan 2012]

Gene Symbol:   CSE1L
Gene Name:   CSE1 chromosome segregation 1-like (yeast)
Aliases:   CAS, CSE1, MGC117283, MGC130036, MGC130037, XPO2
RefSeq:   NC_000020.10 NT_011362.10
Ensembl:   ENSG00000124207
Entrez:   1434
Chromosome Mapping:   20q13

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