PrimePCR™ Probe Assay: HRK, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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PrimePCR™ PreAmp for Probe Assay: HRK, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: HRK, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0039278
Assay Design:   exonic
Chromosome Location:   12:117299146-117299270question
Amplicon Length:   95
Splice Variants Targeted:   ENST00000257572 ENST00000550505

Gene Information

Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain but not with the death-promoting BCL2-related proteins BAX BAK or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL. [provided by RefSeq Jul 2008]

Gene Symbol:   HRK
Gene Name:   harakiri, BCL2 interacting protein (contains only BH3 domain)
Aliases:   DP5, HARAKIRI
RefSeq:   NC_000012.11 NT_009775.17
Ensembl:   ENSG00000135116
Entrez:   8739
Chromosome Mapping:   12q24.22

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