PrimePCR™ Probe Assay: MSR1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: MSR1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: MSR1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049338
Assay Design:   exonic
Chromosome Location:   8:16035403-16035501question
Amplicon Length:   69
Splice Variants Targeted:   ENST00000262101 ENST00000445506 ENST00000355282 ENST00000381998 ENST00000518960 ENST00000518026 ENST00000350896 ENST00000536385

Gene Information

This gene encodes the class A macrophage scavenger receptors which include three different types (1 2 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis Alzheimer's disease and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq Jul 2008]

Gene Symbol:   MSR1
Gene Name:   macrophage scavenger receptor 1
Aliases:   CD204, SCARA1, SR-A, phSR1, phSR2
RefSeq:   NC_000008.10 NT_167187.1 NG_012102.1
Ensembl:   ENSG00000038945
Entrez:   4481
Chromosome Mapping:   8p22

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