PrimePCR™ Probe Assay: ACVR1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: ACVR1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: ACVR1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0050843
Assay Design:   exonic
Chromosome Location:   2:158674976-158675066question
Amplicon Length:   61
Splice Variants Targeted:   ENST00000263640 ENST00000410057 ENST00000412025 ENST00000440523 ENST00000539637 ENST00000424669 ENST00000413751 ENST00000434821

Gene Information

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins composed of a ligand-binding extracellular domain with cysteine-rich region a transmembrane domain and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq Jul 2008]

Gene Symbol:   ACVR1
Gene Name:   activin A receptor, type I
Aliases:   ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
RefSeq:   NC_000002.11 NG_008004.1 NT_005403.17
Ensembl:   ENSG00000115170
Entrez:   90
Chromosome Mapping:   2q23-q24

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