PrimePCR™ Probe Assay: ARRB2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0052281
Assay Design:   exonic
Chromosome Location:   17:4621909-4622605question
Amplicon Length:   69
Splice Variants Targeted:   ENST00000269260 ENST00000574954 ENST00000346341 ENST00000572457 ENST00000381488 ENST00000412477 ENST00000571428 ENST00000575877 ENST00000571206

Gene Information

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones neurotransmitters or sensory signals. Arrestin beta 2 like arrestin beta 1 was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain a cDNA for arrestin beta 2 was isolated from thyroid gland and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Mar 2012]

Gene Symbol:   ARRB2
Gene Name:   arrestin, beta 2
Aliases:   ARB2, ARR2, BARR2, DKFZp686L0365
RefSeq:   NC_000017.10 NT_010718.16
Ensembl:   ENSG00000141480
Entrez:   409
Chromosome Mapping:   17p13

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