PrimePCR™ Probe Assay: IL7R, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: IL7R, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: IL7R, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0057619
Assay Design:   exonic
Chromosome Location:   5:35876996-35877145question
Amplicon Length:   120
Splice Variants Targeted:   ENST00000303115

Gene Information

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor gamma chain (IL2RG) which is a common gamma chain shared by the receptors of various cytokines including interleukine 2 4 7 9 and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq Jul 2008]

Gene Symbol:   IL7R
Gene Name:   interleukin 7 receptor
Aliases:   CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
RefSeq:   NC_000005.9 NG_009567.1 NT_006576.16
Ensembl:   ENSG00000168685
Entrez:   3575
Chromosome Mapping:   5p13

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