PrimePCR™ Probe Assay: LIFR, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: LIFR, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: LIFR, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0058374
Assay Design:   exonic
Chromosome Location:   5:38481779-38481884question
Amplicon Length:   76
Splice Variants Targeted:   ENST00000263409 ENST00000453190

Gene Information

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit gp130 to form a receptor complex that mediates the action of the leukemia inhibitory factor a polyfunctional cytokine that is involved in cellular differentiation proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2 a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1 is associated with salivary gland pleiomorphic adenoma a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   LIFR
Gene Name:   leukemia inhibitory factor receptor alpha
Aliases:   CD118, FLJ98106, FLJ99923, LIF-R, SJS2, STWS, SWS
RefSeq:   NC_000005.9 NT_006576.16 NG_011817.1
Ensembl:   ENSG00000113594
Entrez:   3977
Chromosome Mapping:   5p13-p12

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