PrimePCR™ Probe Assay: NTRK3, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: NTRK3, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: NTRK3, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0026971
Assay Design:   Intron-spanning
Chromosome Location:   15:88690598-88727498question
Amplicon Length:   122
Splice Variants Targeted:   ENST00000394480 ENST00000540489 ENST00000360948 ENST00000357724 ENST00000355254 ENST00000542733 ENST00000343782 ENST00000317501

Gene Information

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that upon neurotrophin binding phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2011]

Gene Symbol:   NTRK3
Gene Name:   neurotrophic tyrosine kinase, receptor, type 3
Aliases:   TRKC, gp145(trkC)
RefSeq:   NC_000015.9 NT_010274.17
Ensembl:   ENSG00000140538
Entrez:   4916
Chromosome Mapping:   15q25

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