PrimePCR™ Probe Assay: ITGA2B, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: ITGA2B, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: ITGA2B, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0028772
Assay Design:   Intron-spanning
Chromosome Location:   17:42453686-42454456question
Amplicon Length:   121
Splice Variants Targeted:   ENST00000262407 ENST00000353281

Gene Information

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq Jul 2008]

Gene Symbol:   ITGA2B
Gene Name:   integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Aliases:   CD41, CD41B, GP2B, GPIIb, GTA, HPA3
RefSeq:   NC_000017.10 NG_008331.1 NT_010783.15
Ensembl:   ENSG00000005961
Entrez:   3674
Chromosome Mapping:   17q21.32

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