PrimePCR™ Probe Assay: TGFBR2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: TGFBR2, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: TGFBR2, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0030460
Assay Design:   Intron-spanning
Chromosome Location:   3:30729901-30732937question
Amplicon Length:   99
Splice Variants Targeted:   ENST00000295754 ENST00000359013 ENST00000439925 ENST00000383765

Gene Information

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome Loeys-Deitz Aortic Aneurysm Syndrome and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq Jul 2008]

Gene Symbol:   TGFBR2
Gene Name:   transforming growth factor, beta receptor II (70/80kDa)
Aliases:   AAT3, FAA3, LDS1B, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
RefSeq:   NC_000003.11 NT_022517.18 NG_007490.1
Ensembl:   ENSG00000163513
Entrez:   7048
Chromosome Mapping:   3p22

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