PrimePCR™ Probe Assay: SOCS2, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0024541
Assay Design:   Exonic
Chromosome Location:   12:93968558-93968737question
Amplicon Length:   150
Splice Variants Targeted:   ENST00000340600 ENST00000549206 ENST00000536696 ENST00000548091 ENST00000549122 ENST00000548537 ENST00000549887 ENST00000551556 ENST00000539385

Gene Information

This gene encodes a member of the STAT-induced STAT inhibitor (SSI) also known as suppressor of cytokine signaling (SOCS) family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines including erythropoietin GM-CSF IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. [provided by RefSeq Jul 2008]

Gene Symbol:   SOCS2
Gene Name:   suppressor of cytokine signaling 2
Aliases:   CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
RefSeq:   NC_000012.11 NT_029419.12
Ensembl:   ENSG00000120833
Entrez:   8835
Chromosome Mapping:   12q

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