PrimePCR™ Probe Assay: MAP2K4, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: MAP2K4, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: MAP2K4, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0040654
Assay Design:   exonic
Chromosome Location:   17:11998933-12011130question
Amplicon Length:   72
Splice Variants Targeted:   ENST00000353533 ENST00000415385 ENST00000582897 ENST00000581941 ENST00000579089

Gene Information

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1 MAPK9/JNK2 and MAPK14/p38 but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development as well as in the organogenesis of liver. [provided by RefSeq Jul 2008]

Gene Symbol:   MAP2K4
Gene Name:   mitogen-activated protein kinase kinase 4
Aliases:   JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1
RefSeq:   NC_000017.10 NT_010718.16
Ensembl:   ENSG00000065559
Entrez:   6416
Chromosome Mapping:   17p11.2

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