PrimePCR™ Probe Assay: RASGRF1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049434
Assay Design:   exonic
Chromosome Location:   15:79254306-79254424question
Amplicon Length:   89
Splice Variants Targeted:   ENST00000558480 ENST00000419573 ENST00000394745

Gene Information

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx muscarinic receptors and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq Mar 2009]

Gene Symbol:   RASGRF1
Gene Name:   Ras protein-specific guanine nucleotide-releasing factor 1
Aliases:   CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187
RefSeq:   NC_000015.9 NT_010194.17
Ensembl:   ENSG00000058335
Entrez:   5923
Chromosome Mapping:   15q24.2

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