PrimePCR™ Probe Assay: BLNK, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0049949
Assay Design:   exonic
Chromosome Location:   10:97951506-97951626question
Amplicon Length:   91
Splice Variants Targeted:   ENST00000427367 ENST00000413476 ENST00000371176 ENST00000224337 ENST00000574984 ENST00000574329

Gene Information

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   BLNK
Gene Name:   B-cell linker
Aliases:   AGM4, BASH, BLNK-S, LY57, MGC111051, SLP-65, SLP65
RefSeq:   NC_000010.10 NT_030059.13 NG_007575.1
Ensembl:   ENSG00000095585
Entrez:   29760
Chromosome Mapping:   10q23.2-q23.33

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