PrimePCR™ Probe Assay: RBBP4, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0053249
Assay Design:   exonic
Chromosome Location:   1:33134850-33135101question
Amplicon Length:   94
Splice Variants Targeted:   ENST00000414241 ENST00000373493 ENST00000373485 ENST00000458695 ENST00000475321 ENST00000463378 ENST00000482190 ENST00000544435

Gene Information

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Sep 2008]

Gene Symbol:   RBBP4
Gene Name:   retinoblastoma binding protein 4
Aliases:   NURF55, RBAP48
RefSeq:   NC_000001.10 NG_012421.1 NT_032977.9
Ensembl:   ENSG00000162521
Entrez:   5928
Chromosome Mapping:   1p35.1

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