PrimePCR™ Probe Assay: PTPN13, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0053373
Assay Design:   exonic
Chromosome Location:   4:87593571-87607880question
Amplicon Length:   114
Splice Variants Targeted:   ENST00000427191 ENST00000502971 ENST00000316707 ENST00000411767 ENST00000507902 ENST00000511467 ENST00000436978

Gene Information

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitotic cycle and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with and dephosphorylate Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants which encode distinct proteins have been reported. [provided by RefSeq Oct 2008]

Gene Symbol:   PTPN13
Gene Name:   protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Aliases:   DKFZp686J1497, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE
RefSeq:   NC_000004.11 NT_016354.19
Ensembl:   ENSG00000163629
Entrez:   5783
Chromosome Mapping:   4q21.3

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