PrimePCR™ Probe Assay: PRKAR2A, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0026352
Assay Design:   Intron-spanning
Chromosome Location:   3:48810419-48820475question
Amplicon Length:   150
Splice Variants Targeted:   ENST00000265563 ENST00000454963 ENST00000296446 ENST00000437821

Gene Information

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq Jul 2008]

Gene Symbol:   PRKAR2A
Gene Name:   protein kinase, cAMP-dependent, regulatory, type II, alpha
Aliases:   MGC3606, PKR2, PRKAR2
RefSeq:   NC_000003.11 NT_022517.18
Ensembl:   ENSG00000114302
Entrez:   5576
Chromosome Mapping:   3p21.3-p21.2

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