PrimePCR™ Probe Assay: TNFRSF10B, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: TNFRSF10B, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: TNFRSF10B, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0026362
Assay Design:   Intron-spanning
Chromosome Location:   8:22886039-22887207question
Amplicon Length:   132
Splice Variants Targeted:   ENST00000276431 ENST00000347739 ENST00000542226

Gene Information

The protein encoded by this gene is a member of the TNF-receptor superfamily and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L) and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD a death domain containing adaptor protein is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq Mar 2009]

Gene Symbol:   TNFRSF10B
Gene Name:   tumor necrosis factor receptor superfamily, member 10b
Aliases:   CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
RefSeq:   NC_000008.10 NG_012145.1 NT_167187.1
Ensembl:   ENSG00000120889
Entrez:   8795
Chromosome Mapping:   8p22-p21

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