PrimePCR™ Probe Assay: MAP4K4, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0027019
Assay Design:   Intron-spanning
Chromosome Location:   2:102490609-102493530question
Amplicon Length:   142
Splice Variants Targeted:   ENST00000425019 ENST00000413150 ENST00000456652 ENST00000347699 ENST00000417294 ENST00000421882 ENST00000324219 ENST00000350198 ENST00000302217 ENST00000350878

Gene Information

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1 MAP2K4/MKK4 and MAP2K7/MKK7 which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Jul 2008]

Gene Symbol:   MAP4K4
Gene Name:   mitogen-activated protein kinase kinase kinase kinase 4
Aliases:   FLH21957, FLJ10410, FLJ20373, FLJ90111, HGK, KIAA0687, NIK
RefSeq:   NC_000002.11 NT_022171.15
Ensembl:   ENSG00000071054
Entrez:   9448
Chromosome Mapping:   2q11.2-q12

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