PrimePCR™ Probe Assay: XRCC5, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0028164
Assay Design:   Intron-spanning
Chromosome Location:   2:216977757-216981455question
Amplicon Length:   140
Splice Variants Targeted:   ENST00000392133 ENST00000417391 ENST00000392132

Gene Information

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6 a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq Jul 2008]

Gene Symbol:   XRCC5
Gene Name:   X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Aliases:   FLJ39089, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV
RefSeq:   NC_000002.11 NT_005403.17
Ensembl:   ENSG00000079246
Entrez:   7520
Chromosome Mapping:   2q35

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