PrimePCR™ Probe Assay: PDGFRB, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0028803
Assay Design:   Intron-spanning
Chromosome Location:   5:149500804-149501507question
Amplicon Length:   117
Splice Variants Targeted:   ENST00000261799 ENST00000544453

Gene Information

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12 that fuses this gene to that of the translocation ETV6 leukemia gene results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq Jul 2008]

Gene Symbol:   PDGFRB
Gene Name:   platelet-derived growth factor receptor, beta polypeptide
Aliases:   CD140B, JTK12, PDGFR, PDGFR1
RefSeq:   NC_000005.9 NG_012303.1 NG_023367.1 NT_029289.11
Ensembl:   ENSG00000113721
Entrez:   5159
Chromosome Mapping:   5q33.1

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