PrimePCR™ Probe Assay: RET, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0028808
Assay Design:   Intron-spanning
Chromosome Location:   10:43607563-43608335question
Amplicon Length:   115
Splice Variants Targeted:   ENST00000355710 ENST00000498820 ENST00000340058

Gene Information

This gene a member of the cadherin superfamily encodes one of the receptor tyrosine kinases which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia type IIA multiple endocrine neoplasia type IIB Hirschsprung disease and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq Jul 2008]

Gene Symbol:   RET
Gene Name:   ret proto-oncogene
Aliases:   CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
RefSeq:   NC_000010.10 NT_033985.7 NG_007489.1
Ensembl:   ENSG00000165731
Entrez:   5979
Chromosome Mapping:   10q11.2

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