PrimePCR™ Probe Assay: GNB3, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0028951
Assay Design:   Intron-spanning
Chromosome Location:   12:6950751-6952384question
Amplicon Length:   162
Splice Variants Targeted:   ENST00000229264 ENST00000541257 ENST00000541978 ENST00000435982 ENST00000537035

Gene Information

Heterotrimeric guanine nucleotide-binding proteins (G proteins) which integrate signals between receptors and effector proteins are composed of an alpha a beta and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene but they have not been fully described. [provided by RefSeq Jul 2008]

Gene Symbol:   GNB3
Gene Name:   guanine nucleotide binding protein (G protein), beta polypeptide 3
Aliases:   Not Available
RefSeq:   NC_000012.11 NG_009100.1 NT_009759.16
Ensembl:   ENSG00000111664
Entrez:   2784
Chromosome Mapping:   12p13

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