PrimePCR™ Probe Assay: ACE, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: ACE, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: ACE, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0031511
Assay Design:   Intron-spanning
Chromosome Location:   17:61562709-61564027question
Amplicon Length:   105
Splice Variants Targeted:   ENST00000290866 ENST00000428043 ENST00000290863 ENST00000413513 ENST00000421982

Gene Information

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified and two most abundant spliced variants encode the somatic form and the testicular form respectively that are equally active. [provided by RefSeq May 2010]

Gene Symbol:   ACE
Gene Name:   angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Aliases:   ACE1, CD143, DCP, DCP1, MGC26566, MVCD3
RefSeq:   NC_000017.10 NG_011648.1 NT_010783.15
Ensembl:   ENSG00000159640
Entrez:   1636
Chromosome Mapping:   17q23.3

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