PrimePCR™ Probe Assay: ERBB3, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

List Price:    $263.00
Your Price:   Log In
 

Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0031829
Assay Design:   Intron-spanning
Chromosome Location:   12:56477584-56478821question
Amplicon Length:   116
Splice Variants Targeted:   ENST00000549282 ENST00000549061 ENST00000267101 ENST00000411731 ENST00000549672 ENST00000415288 ENST00000394099

Gene Information

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. [provided by RefSeq Jul 2008]

Gene Symbol:   ERBB3
Gene Name:   v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Aliases:   ErbB-3, HER3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
RefSeq:   NC_000012.11 NT_029419.12 NG_011529.1
Ensembl:   ENSG00000065361
Entrez:   2065
Chromosome Mapping:   12q13

[ Close ]
Click here to print
[ Close ]
Click here to print
 

undefined

undefined

My PrimePCR Hot List stores your saved PrimePCR products and configurations

My PrimePCR Hot List stores your saved PrimePCR products and configurations

undefined

undefined

undefined

undefined

undefined

undefined

undefined