PrimePCR™ Probe Assay: MAPK9, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0039035
Assay Design:   Intron-spanning
Chromosome Location:   5:179691783-179696372question
Amplicon Length:   120
Splice Variants Targeted:   ENST00000452135 ENST00000393360 ENST00000455781 ENST00000343111 ENST00000347470 ENST00000425491 ENST00000523583 ENST00000539014 ENST00000397072

Gene Information

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation differentiation transcription regulation and development. This kinase targets specific transcription factors and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8 both of which are involved in UV radiation induced apoptosis thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53 and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq Sep 2008]

Gene Symbol:   MAPK9
Gene Name:   mitogen-activated protein kinase 9
Aliases:   JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, p54a, p54aSAPK
RefSeq:   NC_000005.9 NT_023133.13
Ensembl:   ENSG00000050748
Entrez:   5601
Chromosome Mapping:   5q35

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