PrimePCR™ Probe Assay: IL7, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0040328
Assay Design:   exonic
Chromosome Location:   8:79710307-79710412question
Amplicon Length:   76
Splice Variants Targeted:   ENST00000263851 ENST00000520269 ENST00000379113

Gene Information

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq Dec 2010]

Gene Symbol:   IL7
Gene Name:   interleukin 7
Aliases:   IL-7
RefSeq:   NC_000008.10 NT_008183.19
Ensembl:   ENSG00000104432
Entrez:   3574
Chromosome Mapping:   8q12-q13

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