PrimePCR™ Probe Assay: INHBB, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0053297
Assay Design:   exonic
Chromosome Location:   2:121107516-121107630question
Amplicon Length:   85
Splice Variants Targeted:   ENST00000295228

Gene Information

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore the beta B subunit forms a homodimer activin B and also joins with the beta A subunit to form a heterodimer activin AB both of which stimulate FSH secretion. [provided by RefSeq Jul 2008]

Gene Symbol:   INHBB
Gene Name:   inhibin, beta B
Aliases:   MGC157939
RefSeq:   NC_000002.11 NT_022135.16
Ensembl:   ENSG00000163083
Entrez:   3625
Chromosome Mapping:   2cen-q13

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