PrimePCR™ Probe Assay: BCR, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0028933
Assay Design:   Intron-spanning
Chromosome Location:   22:23613739-23615922question
Amplicon Length:   166
Splice Variants Targeted:   ENST00000305877 ENST00000359540 ENST00000427791 ENST00000334149

Gene Information

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   BCR
Gene Name:   breakpoint cluster region
Aliases:   ALL, BCR1, CML, D22S11, D22S662, FLJ16453, PHL
RefSeq:   NC_000022.10 NG_009244.1 NT_011520.12
Ensembl:   ENSG00000186716
Entrez:   613
Chromosome Mapping:   22q11,22q11.23

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