PrimePCR™ Probe Assay: IL4, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCIP0028968
Assay Design:   Intron-spanning
Chromosome Location:   5:132009799-132015477question
Amplicon Length:   121
Splice Variants Targeted:   ENST00000231449 ENST00000350025

Gene Information

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13 which may contribute to many overlapping functions of this cytokine and IL13. STAT6 a signal transducer and activator of transcription has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene IL3 IL5 IL13 and CSF2 form a cytokine gene cluster on chromosome 5q with this gene particularly close to IL13. This gene IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq Jul 2008]

Gene Symbol:   IL4
Gene Name:   interleukin 4
Aliases:   BCGF-1, BCGF1, BSF1, IL-4, MGC79402
RefSeq:   NC_000005.9 NG_023252.1 NT_034772.6
Ensembl:   ENSG00000113520
Entrez:   3565
Chromosome Mapping:   5q31.1

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