PrimePCR™ Probe Assay: CFL1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0025424
Assay Design:   Exonic
Chromosome Location:   11:65622318-65622468question
Amplicon Length:   121
Splice Variants Targeted:   ENST00000525451 ENST00000308162

Gene Information

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM Apr 2004]

Gene Symbol:   CFL1
Gene Name:   cofilin 1 (non-muscle)
Aliases:   CFL
RefSeq:   NC_000011.9 NT_167190.1
Ensembl:   ENSG00000172757
Entrez:   1072
Chromosome Mapping:   11q13

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