PrimePCR™ Probe Assay: HTR2A, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: HTR2A, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: HTR2A, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0039107
Assay Design:   exonic
Chromosome Location:   13:47466542-47466691question
Amplicon Length:   120
Splice Variants Targeted:   ENST00000378688 ENST00000543956 ENST00000542664

Gene Information

This gene encodes one of the receptors for serotonin a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Sep 2009]

Gene Symbol:   HTR2A
Gene Name:   5-hydroxytryptamine (serotonin) receptor 2A
Aliases:   5-HT2A, HTR2
RefSeq:   NC_000013.10 NG_013011.1 NT_024524.14
Ensembl:   ENSG00000102468
Entrez:   3356
Chromosome Mapping:   13q14-q21

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