PrimePCR™ Probe Assay: BCL6, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: BCL6, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: BCL6, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0050789
Assay Design:   exonic
Chromosome Location:   3:187449577-187449706question
Amplicon Length:   100
Splice Variants Targeted:   ENST00000438077 ENST00000430339 ENST00000450123 ENST00000232014 ENST00000406870

Gene Information

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq Sep 2008]

Gene Symbol:   BCL6
Gene Name:   B-cell CLL/lymphoma 6
Aliases:   BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
RefSeq:   NC_000003.11 NT_005612.16 NG_007149.1
Ensembl:   ENSG00000113916
Entrez:   604
Chromosome Mapping:   3q27

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