PrimePCR™ Probe Assay: XPC, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: XPC, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: XPC, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0052912
Assay Design:   exonic
Chromosome Location:   3:14211969-14214381question
Amplicon Length:   67
Splice Variants Targeted:   ENST00000285021 ENST00000511155 ENST00000449060

Gene Information

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway including Xeroderma pigmentosum (XP) A-G and V Cockayne syndrome (CS) A and B and trichothiodystrophy (TTD) group A etc. This component XPC plays an important role in the early steps of global genome NER especially in damage recognition open complex formation and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq Mar 2009]

Gene Symbol:   XPC
Gene Name:   xeroderma pigmentosum, complementation group C
Aliases:   RAD4, XP3, XPCC
RefSeq:   NC_000003.11 NG_008975.1 NT_022517.18 NG_011763.1
Ensembl:   ENSG00000154767
Entrez:   7508
Chromosome Mapping:   3p25

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