PrimePCR™ Probe Assay: RRM1, Human

RT

Real-time PCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

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PrimePCR™ PreAmp for Probe Assay: RRM1, Human
Reaction:     400 reactions
Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.

PrimePCR™ Template for Probe Assay: RRM1, Human
Reaction:     200 x 20 µl reactions
Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe assay.


Wet Lab Validated

Assay Information

Technology:   qPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   qHsaCEP0058446
Assay Design:   exonic
Chromosome Location:   11:4139602-4141080question
Amplicon Length:   66
Splice Variants Targeted:   ENST00000300738 ENST00000534285 ENST00000423050 ENST00000537197

Gene Information

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5 an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome Wilms tumor rhabdomyosarcoma adrenocrotical carcinoma and lung ovarian and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq Jul 2008]

Gene Symbol:   RRM1
Gene Name:   ribonucleotide reductase M1
Aliases:   R1, RIR1, RR1
RefSeq:   NC_000011.9 NG_016277.1 NG_027992.1 NT_009237.18
Ensembl:   ENSG00000167325
Entrez:   6240
Chromosome Mapping:   11p15.5

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